Dopamine D3 receptor

Definition:

Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation.

References:

[1]. Laura Albizu, et al. Functional crosstalk and heteromerization of serotonin 5-HT2A and dopamine D2 receptors. Neuropharmacology. 2011 Sep;61(4):770-7. [Content Brief]

[2]. Sheng Wang, et al. D4 dopamine receptor high-resolution structures enable the discovery of selective agonists. Science. 2017 Oct 20;358(6361):381-386. [Content Brief]

[3]. V Asghari, et al. Modulation of intracellular cyclic AMP levels by different human dopamine D4 receptor variants. J Neurochem. 1995 Sep;65(3):1157-65. [Content Brief]

[4]. F Lanau, et al. Epinephrine and norepinephrine act as potent agonists at the recombinant human dopamine D4 receptor. J Neurochem. 1997 Feb;68(2):804-12. [Content Brief]

[5]. V Asghari, et al. Dopamine D4 receptor repeat: analysis of different native and mutant forms of the human and rat genes. Mol Pharmacol. 1994 Aug;46(2):364-73. [Content Brief]

[6]. C L Chio, et al. D4 dopamine receptor-mediated signaling events determined in transfected Chinese hamster ovary cells. J Biol Chem. 1994 Apr 22;269(16):11813-9. [Content Brief]

[7]. H H Van Tol, et al. Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine. Nature. 1991 Apr 18;350(6319):610-4. [Content Brief]

[8]. R L Weinshank, et al. Molecular cloning and characterization of a high affinity dopamine receptor (D1 beta) and its pseudogene. J Biol Chem. 1991 Nov 25;266(33):22427-35. [Content Brief]

[9]. Van Anthony M Villar, et al. G protein-coupled receptor kinase 4 (GRK4) regulates the phosphorylation and function of the dopamine D3 receptor. J Biol Chem. 2009 Aug 7;284(32):21425-34. [Content Brief]

[10]. Xiaowei Zhang, et al. Palmitoylation of the carboxyl-terminal tail of dopamine D4 receptor is required for surface expression, endocytosis, and signaling. Biochem Biophys Res Commun. 2016 Oct 14;479(2):398-403. [Content Brief]

[11]. Christoph Czermak, et al. [35S]GTPgammaS binding at the human dopamine D4 receptor variants hD4.2, hD4.4 and hD4.7 following stimulation by dopamine, epinephrine and norepinephrine. Eur J Pharmacol. 2006 Feb 15;531(1-3):20-4. [Content Brief]

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