Dual specificity mitogen-activated protein kinase kinase 2

Definition:

Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity). Activates BRAF in a KSR1 or KSR2-dependent manner; by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation.

References:

[1]. Hugo Lavoie, et al. MEK drives BRAF activation through allosteric control of KSR proteins. Nature. 2018 Feb 22;554(7693):549-553. [Content Brief]

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