Dual specificity protein phosphatase 10

Definition:

Protein phosphatase involved in the inactivation of MAP kinases. Has a specificity for the MAPK11/MAPK12/MAPK13/MAPK14 subfamily. It preferably dephosphorylates p38.

References:

[1]. T Tanoue, et al. Molecular cloning and characterization of a novel dual specificity phosphatase, MKP-5. J Biol Chem. 1999 Jul 9;274(28):19949-56. [Content Brief]

[2]. A Theodosiou, et al. MKP5, a new member of the MAP kinase phosphatase family, which selectively dephosphorylates stress-activated kinases. Oncogene. 1999 Nov 25;18(50):6981-8. [Content Brief]

[3]. Yuan-Yuan Zhang, et al. A distinct interaction mode revealed by the crystal structure of the kinase p38α with the MAPK binding domain of the phosphatase MKP5. Sci Signal. 2011 Dec 20;4(204):ra88. [Content Brief]

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