Dual specificity protein phosphatase 13 isoform A

Definition:

Probable protein tyrosine phosphatase. Has phosphatase activity with synthetic substrates. Has a phosphatase activity-independent regulatory role in MAP3K5/ASK1-mediated apoptosis, preventing MAP3K5/ASK1 inhibition by AKT1. Shows no phosphatase activity on MAPK1/ERK2, MAPK8/JNK, MAPK14/p38 and MAP3K5/ASK1.

References:

[1]. Chun Hwa Wei, et al. Two intermediate states of the conformational switch in dual specificity phosphatase 13a. Pharmacol Res. 2018 Feb;128:211-219. [Content Brief]

[2]. Jae Eun Park, et al. Positive regulation of apoptosis signal-regulating kinase 1 by dual-specificity phosphatase 13A. Cell Mol Life Sci. 2010 Aug;67(15):2619-29. [Content Brief]

[3]. Hsu-Hsin Chen, et al. Characterization of two distinct dual specificity phosphatases encoded in alternative open reading frames of a single gene located on human chromosome 10q22.2. J Biol Chem. 2004 Oct 1;279(40):41404-13. [Content Brief]

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