Dual specificity protein phosphatase CDC14A

Definition:

Dual-specificity phosphatase. Required for centrosome separation and productive cytokinesis during cell division. Dephosphorylates SIRT2 around early anaphase. May dephosphorylate the APC subunit FZR1/CDH1, thereby promoting APC-FZR1 dependent degradation of mitotic cyclins and subsequent exit from mitosis. Required for normal hearing.

References:

[1]. Ayesha Imtiaz, et al. CDC14A phosphatase is essential for hearing and male fertility in mouse and human. Hum Mol Genet. 2018 Mar 1;27(5):780-798. [Content Brief]

[2]. Brian J North, et al. Mitotic regulation of SIRT2 by cyclin-dependent kinase 1-dependent phosphorylation. J Biol Chem. 2007 Jul 6;282(27):19546-55. [Content Brief]

[3]. Niels Mailand, et al. Deregulated human Cdc14A phosphatase disrupts centrosome separation and chromosome segregation. Nat Cell Biol. 2002 Apr;4(4):317-22. [Content Brief]

[4]. L Li, et al. A family of putative tumor suppressors is structurally and functionally conserved in humans and yeast. J Biol Chem. 1997 Nov 21;272(47):29403-6. [Content Brief]

[5]. Brett K Kaiser, et al. Disruption of centrosome structure, chromosome segregation, and cytokinesis by misexpression of human Cdc14A phosphatase. Mol Biol Cell. 2002 Jul;13(7):2289-300. [Content Brief]

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