E3 ubiquitin-protein ligase listerin

Definition:

E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. Ubiquitination leads to VCP/p97 recruitment for extraction and degradation of the incomplete translation product (By similarity).

References:

[1]. Sichen Shao, et al. Structure and assembly pathway of the ribosome quality control complex. Mol Cell. 2015 Feb 5;57(3):433-44. [Content Brief]

[2]. Yoshitaka Matsuo, et al. Ubiquitination of stalled ribosome triggers ribosome-associated quality control. Nat Commun. 2017 Jul 31;8(1):159. [Content Brief]

[3]. Sichen Shao, et al. Listerin-dependent nascent protein ubiquitination relies on ribosome subunit dissociation. Mol Cell. 2013 Jun 6;50(5):637-48. [Content Brief]

[4]. Sichen Shao, et al. Reconstitution of a minimal ribosome-associated ubiquitination pathway with purified factors. Mol Cell. 2014 Sep 18;55(6):880-890. [Content Brief]

Biomedical Dictionary

The Biomedical Dictionary is a comprehensive and professional collection of biological academic terms and subject datas. All explanations are supported by authoritative books or high impact factor literatures, and you can acquire accurate explanations of the biomedical terms you want to know.

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z #

Name
Email *

	Sorry, but the email address you supplied was invalid.