E3 ubiquitin-protein ligase MARCHF1

Definition:

E3 ubiquitin-protein ligase that mediates ubiquitination of TFRC, CD86, FAS and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. By constitutively ubiquitinating MHC class II proteins in immature dendritic cells, down-regulates their cell surface localization thus sequestering them in the intracellular endosomal system.

References:

[1]. Nicolas Lapaque, et al. The HLA-DRalpha chain is modified by polyubiquitination. J Biol Chem. 2009 Mar 13;284(11):7007-16. [Content Brief]

[2]. Jacques Thibodeau, et al. Interleukin-10-induced MARCH1 mediates intracellular sequestration of MHC class II in monocytes. Eur J Immunol. 2008 May;38(5):1225-30. [Content Brief]

[3]. Eric Bartee, et al. Downregulation of major histocompatibility complex class I by human ubiquitin ligases related to viral immune evasion proteins. J Virol. 2004 Feb;78(3):1109-20. [Content Brief]

[4]. Aude De Gassart, et al. MHC class II stabilization at the surface of human dendritic cells is the result of maturation-dependent MARCH I down-regulation. Proc Natl Acad Sci U S A. 2008 Mar 4;105(9):3491-6. [Content Brief]

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