E3 ubiquitin-protein ligase RNF152

Definition:

E3 ubiquitin-protein ligase mediating 'Lys-63'-linked polyubiquitination of RRAGA in response to amino acid starvation. Thereby, regulates mTORC1 signaling and plays a role in the cellular response to amino acid availability. Also mediates 'Lys-48'-linked polyubiquitination of target proteins and their subsequent targeting to the proteasome for degradation. Induces apoptosis when overexpressed.

References:

[1]. Songling Zhang, et al. RNF152, a novel lysosome localized E3 ligase with pro-apoptotic activities. Protein Cell. 2010 Jul;1(7):656-63. [Content Brief]

[2]. Lu Deng, et al. The ubiquitination of rag A GTPase by RNF152 negatively regulates mTORC1 activation. Mol Cell. 2015 Jun 4;58(5):804-18. [Content Brief]

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