E3 ubiquitin-protein ligase TRIM58

Definition:

E3 ubiquitin ligase induced during late erythropoiesis. Directly binds and ubiquitinates the intermediate chain of the microtubule motor dynein (DYNC1LI1/DYNC1LI2), stimulating the degradation of the dynein holoprotein complex. May participate in the erythroblast enucleation process through regulation of nuclear polarization.

References:

[1]. Christopher S Thom, et al. Trim58 degrades Dynein and regulates terminal erythropoiesis. Dev Cell. 2014 Sep 29;30(6):688-700. [Content Brief]

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