Ecto-NOX disulfide-thiol exchanger 1

Definition:

Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface. Hydroquinone oxidase activity alternates with a protein disulfide-thiol interchange/oxidoreductase activity which may control physical membrane displacements associated with vesicle budding or cell enlargement. The activities oscillate with a period length of 24 minutes and play a role in control of the ultradian cellular biological clock.

References:

[1]. Ziying Jiang, et al. A role for copper in biological time-keeping. J Inorg Biochem. 2006 Dec;100(12):2140-9. [Content Brief]

[2]. D Sedlak, et al. A drug-unresponsive and protease-resistant CNOX protein from human sera. Arch Biochem Biophys. 2001 Feb 1;386(1):106-16. [Content Brief]

[3]. Sui Wang, et al. Sera from cancer patients contain two oscillating ECTO-NOX activities with different period lengths. Cancer Lett. 2003 Feb 20;190(2):135-41. [Content Brief]

[4]. Ziying Jiang, et al. Molecular cloning and characterization of a candidate human growth-related and time-keeping constitutive cell surface hydroquinone (NADH) oxidase. Biochemistry. 2008 Dec 30;47(52):14028-38. [Content Brief]

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