Endothelial cell-specific chemotaxis regulator

Definition:

Regulates endothelial chemotaxis and tube formation. Has a role in angiogenesis and apoptosis via modulation of the actin cytoskeleton and facilitation of proteasomal degradation of the apoptosis inhibitors BIRC3/IAP1 and BIRC2/IAP2.

References:

[1]. Laura-Jane Armstrong, et al. ECSM2, an endothelial specific filamin a binding protein that mediates chemotaxis. Arterioscler Thromb Vasc Biol. 2008 Sep;28(9):1640-6. [Content Brief]

[2]. Koji Ikeda, et al. Identification of ARIA regulating endothelial apoptosis and angiogenesis by modulating proteasomal degradation of cIAP-1 and cIAP-2. Proc Natl Acad Sci U S A. 2009 May 19;106(20):8227-32. [Content Brief]

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