Endothelial differentiation-related factor 1

Definition:

Transcriptional coactivator stimulating NR5A1 and ligand-dependent NR1H3/LXRA and PPARG transcriptional activities. Enhances the DNA-binding activity of ATF1, ATF2, CREB1 and NR5A1. Regulates nitric oxid synthase activity probably by sequestering calmodulin in the cytoplasm. May function in endothelial cells differentiation, hormone-induced cardiomyocytes hypertrophy and lipid metabolism.

References:

[1]. Y Kabe, et al. The role of human MBF1 as a transcriptional coactivator. J Biol Chem. 1999 Nov 26;274(48):34196-202. [Content Brief]

[2]. I Dragoni, et al. EDF-1, a novel gene product down-regulated in human endothelial cell differentiation. J Biol Chem. 1998 Nov 20;273(47):31119-24. [Content Brief]

[3]. Carole Brendel, et al. Multiprotein bridging factor-1 (MBF-1) is a cofactor for nuclear receptors that regulate lipid metabolism. Mol Endocrinol. 2002 Jun;16(6):1367-77. [Content Brief]

[4]. E Ballabio, et al. The dual role of endothelial differentiation-related factor-1 in the cytosol and nucleus: modulation by protein kinase A. Cell Mol Life Sci. 2004 May;61(9):1069-74. [Content Brief]

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