Energy coupling factor (ECF) transporter

Definition:

Energy coupling factor (ECF) transporters are a subgroup of ATP-binding cassette (ABC) transporters involved in the uptake of vitamins and micronutrients in prokaryotes. In contrast to classical ABC importers, ECF transporters do not make use of water-soluble substrate binding proteins or domains but instead employ integral membrane proteins for substrate binding (named S-components). S-components form active translocation complexes with the ECF module, an assembly of two nucleotide-binding domains (NBDs, or EcfA) and a second transmembrane protein.

References:

[1]. Guus B Erkens, et al. Energy coupling factor-type ABC transporters for vitamin uptake in prokaryotes. Biochemistry. 2012 Jun 5;51(22):4390-6. [Content Brief]

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