Eosinophilic esophagitis

Definition:

Eosinophilic esophagitis (EoE) is a chronic immune and antigen-mediated clinicopathologic disease that is characterized by eosinophil infiltration into the esophageal epithelium and results in esophageal fibrosis and dysfunction. Several factors contribute to the development of EoE, including genetic predisposition, history of allergies, and presence of environmental and food allergens. Recently, an association between a single nuclear polymorphism (SNP) in the gene encoding thymic stromal lymphopoietin (TSLP) or eotaxin-3 (CCL-26) and risk for EoE was found.

References:

[1]. A Straumann, et al. Pediatric and adult eosinophilic esophagitis: similarities and differences. Allergy. 2012 Apr;67(4):477-90. [Content Brief]

[2]. Carine Blanchard, et al. Eosinophilic esophagitis: pathogenesis, genetics, and therapy. J Allergy Clin Immunol. 2006 Nov;118(5):1054-9. [Content Brief]

[3]. D J Mulder, et al. Understanding eosinophilic esophagitis: the cellular and molecular mechanisms of an emerging disease. Mucosal Immunol. 2011 Mar;4(2):139-47. [Content Brief]

[4]. Erminia Ridolo, et al. Eosinophilic esophagitis: which role for food and inhalant allergens?. Asia Pac Allergy. 2012 Oct;2(4):237-41. [Content Brief]

[5]. Ghulamullah Shahzad, et al. Role of mucosal inflammation in eosinophilic esophagitis: review of the literature. ISRN Gastroenterol. 2011;2011:468073. [Content Brief]

[6]. J Pablo Abonia, et al. Eosinophilic esophagitis: rapidly advancing insights. Annu Rev Med. 2012;63:421-34. [Content Brief]

[7]. Jamie Merves, et al. Eosinophilic esophagitis. Ann Allergy Asthma Immunol. 2014 May;112(5):397-403. [Content Brief]

[8]. Matthew Redd, et al. Eosinophilic esophagitis: current treatment. Dig Dis Sci. 2013 Mar;58(3):613-20. [Content Brief]

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