Epidermodysplasia verruciformis

Definition:

Epidermodysplasia verruciformis (EV) is a rare autosomal recessive genodermatosis, which is characterized by persistent human papillomavirus infection. The clinical features are lifelong eruption of pityriasis versicolor-like macules, flat wart-like papules and development of cutaneous carcinomas.

References:

[1]. Amandine Crequer, et al. Human RHOH deficiency causes T cell defects and susceptibility to EV-HPV infections. J Clin Invest. 2012 Sep;122(9):3239-47. [Content Brief]

[2]. Aron Gewirtzman, et al. Epidermodysplasia verruciformis and human papilloma virus. Curr Opin Infect Dis. 2008 Apr;21(2):141-6. [Content Brief]

[3]. Liran Horev, et al. Generalized verrucosis and HPV-3 susceptibility associated with CD4 T-cell lymphopenia caused by inherited human interleukin-7 deficiency. J Am Acad Dermatol. 2015 Jun;72(6):1082-4. [Content Brief]

[4]. Sarah Jill de Jong, et al. The human CIB1-EVER1-EVER2 complex governs keratinocyte-intrinsic immunity to β-papillomaviruses. J Exp Med. 2018 Sep 3;215(9):2289-2310. [Content Brief]

[5]. Ulker Gül, et al. Clinical aspects of epidermodysplasia verruciformis and review of the literature. Int J Dermatol. 2007 Oct;46(10):1069-72. [Content Brief]

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