ER degradation-enhancing alpha-mannosidase-like protein 2

Definition:

Involved in the endoplasmic reticulum-associated degradation (ERAD) pathway that targets misfolded glycoproteins for degradation in an N-glycan-dependent manner. May initiate ERAD by promoting the first mannose trimming step of ERAD substrates, from Man9GlcNAc2 to Man8GlcNAc2. Seems to recognize and bind to exposed hydrophobic regions in target proteins (By similarity).

References:

[1]. Satoshi Ninagawa, et al. EDEM2 initiates mammalian glycoprotein ERAD by catalyzing the first mannose trimming step. J Cell Biol. 2014 Aug 4;206(3):347-56. [Content Brief]

[2]. Steven W Mast, et al. Human EDEM2, a novel homolog of family 47 glycosidases, is involved in ER-associated degradation of glycoproteins. Glycobiology. 2005 Apr;15(4):421-36. [Content Brief]

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