Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial

Definition:

Adapter protein of the Toll-like and IL-1 receptor signaling pathway that is involved in the activation of NF-kappa-B via MAP3K1 and activation of IRF3/IRF7 pathways. Promotes proteolytic activation of MAP3K1. Involved in the BMP signaling pathway. Required for normal embryonic development (By similarity).; As part of the MCIA complex, involved in the assembly of the mitochondrial complex I.

References:

[1]. Takeshi Kondo, et al. TRIM59 interacts with ECSIT and negatively regulates NF-κB and IRF-3/7-mediated signal pathways. Biochem Biophys Res Commun. 2012 Jun 8;422(3):501-7. [Content Brief]

[2]. Luke E Formosa, et al. Dissecting the Roles of Mitochondrial Complex I Intermediate Assembly Complex Factors in the Biogenesis of Complex I. Cell Rep. 2020 Apr 21;31(3):107541. [Content Brief]

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