Extracellular-regulated kinase 1/2 (ERK1/2)

Definition:

Extracellular signal-regulated kinase 1/2 (ERK1/2) is an important member of the Mitogen-activated protein kinase (MAPK) family, is found in many organisms, and it participates in intracellular signal transduction. Phosphorylated ERK1/2 moves to the nucleus, activates many transcription factors, regulates gene expression, and controls various physiological processes, finally inducing repair processes or cell death.

References:

[1]. Kong T, et al. Role of the Extracellular Signal-Regulated Kinase 1/2 Signaling Pathway in Ischemia-Reperfusion Injury. Front Physiol. 2019 Aug 14;10:1038. [Content Brief]

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