F-actin-capping protein subunit alpha-1

Definition:

F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the formation of epithelial cell junctions.

References:

[1]. Ahmed Elbediwy, et al. Epithelial junction formation requires confinement of Cdc42 activity by a novel SH3BP1 complex. J Cell Biol. 2012 Aug 20;198(4):677-93. [Content Brief]

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