F-actin-uncapping protein LRRC16A

Definition:

Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization, however, seems unable to nucleate filaments. Plays a role in lamellipodial protrusion formations and cell migration.

References:

[1]. Yun Liang, et al. Distinct roles for CARMIL isoforms in cell migration. Mol Biol Cell. 2009 Dec;20(24):5290-305. [Content Brief]

[2]. Changsong Yang, et al. Mammalian CARMIL inhibits actin filament capping by capping protein. Dev Cell. 2005 Aug;9(2):209-21. [Content Brief]

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