Familial breast-ovarian cancer

Definition:

Hereditary susceptibility to breast cancer is considered to be polygenic. The most important breast cancer susceptibility genes are BRCA1 and BRCA2. Mutations in these genes confer a high risk of early-onset breast cancer and also an increased risk of ovarian cancer. Recently, mutations in RAD51C and RAD51D were identified in families with breast and ovarian cancer.

References:

[1]. Chey Loveday, et al. Germline mutations in RAD51D confer susceptibility to ovarian cancer. Nat Genet. 2011 Aug 7;43(9):879-882. [Content Brief]

[2]. Liisa M Pelttari, et al. RAD51C is a susceptibility gene for ovarian cancer. Hum Mol Genet. 2011 Aug 15;20(16):3278-88. [Content Brief]

[3]. P L Welcsh, et al. BRCA1 and BRCA2 and the genetics of breast and ovarian cancer. Hum Mol Genet. 2001 Apr;10(7):705-13. [Content Brief]

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