Fibrillin-2 [Cleaved into: Placensin]

Definition:

[Fibrillin-2]: Fibrillins are structural components of 10-12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. Fibrillin-2-containing microfibrils regulate the early process of elastic fiber assembly. Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively.; [Placensin]: Hormone secreted by trophoblasts that promotes trophoblast invasiveness. Has glucogenic activity: is able to increase plasma glucose levels (By similarity).

References:

[1]. Yiping Yu, et al. Placensin is a glucogenic hormone secreted by human placenta. EMBO Rep. 2020 Jun 4;21(6):e49530. [Content Brief]

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