Fibroblast growth factor receptor substrate 3

Definition:

Adapter protein that links FGF and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Down-regulates ERK2 signaling by interfering with the phosphorylation and nuclear translocation of ERK2.

References:

[1]. Noriko Gotoh, et al. FRS2 family docking proteins with overlapping roles in activation of MAP kinase have distinct spatial-temporal patterns of expression of their transcripts. FEBS Lett. 2004 Apr 23;564(1-2):14-8. [Content Brief]

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