Fisher syndrome

Definition:

Fisher syndrome is a variant of the Guillain- Barre syndrome (GBS) and its classical clinical triad consists of ophthalmoplegia, ataxia, and areflexia. It is a relatively rare neurological disorder, accounting for approximately 5% of acute inflammatory polyneuropathies. This disease is an immune-mediated condition and specific anti-ganglioside antibodies, especially IgG anti-GQ1b antibodies, are found in over 80% of the patients. Campylobacter and Haemophilus influenzae have been reported as infectious agents prior to the onset of Fisher syndrome. It has been reported that the median period required for the disappearance of ataxia was about 1 month, without therapy.

References:

[1]. Ioannis E Dagklis, et al. Miller-Fisher Syndrome: Are Anti-GAD Antibodies Implicated in Its Pathophysiology?. Case Rep Neurol Med. 2016;2016:3431849. [Content Brief]

[2]. Masahiro Mori, et al. Fisher syndrome. Curr Treat Options Neurol. 2011 Feb;13(1):71-8. [Content Brief]

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