Follicle-stimulating hormone receptor

Definition:

G protein-coupled receptor for follitropin, the follicle-stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways.

References:

[1]. Xuliang Jiang, et al. Evidence for Follicle-stimulating Hormone Receptor as a Functional Trimer. J Biol Chem. 2014 May 16;289(20):14273-82. [Content Brief]

[2]. S Costagliola, et al. Tyrosine sulfation is required for agonist recognition by glycoprotein hormone receptors. EMBO J. 2002 Feb 15;21(4):504-13. [Content Brief]

[3]. Sayaka Uchida, et al. Molecular analysis of a mutated FSH receptor detected in a patient with spontaneous ovarian hyperstimulation syndrome. PLoS One. 2013 Sep 13;8(9):e75478. [Content Brief]

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