Globozoospermia

Definition:

Globozoospermia is a rare form of teratozoospermia, mainly characterized by round-headed spermatozoa that lack an acrosome. Acrosome plays an important role at the site of sperm-zona pellucida binding during the fertilization process. It was suggested that a homozygous mutation in SPATA16 was associated with male infertility in human globozoospermia. It has also been reported that a recurrent deletion of DPY19L2 causes infertility in man by blocking sperm head elongation and acrosome formation.

References:

[1]. Anika H D M Dam, et al. Homozygous mutation in SPATA16 is associated with male infertility in human globozoospermia. Am J Hum Genet. 2007 Oct;81(4):813-20. [Content Brief]

[2]. Gang Liu, et al. A newly discovered mutation in PICK1 in a human with globozoospermia. Asian J Androl. 2010 Jul;12(4):556-60. [Content Brief]

[3]. Radu Harbuz, et al. A recurrent deletion of DPY19L2 causes infertility in man by blocking sperm head elongation and acrosome formation. Am J Hum Genet. 2011 Mar 11;88(3):351-61. [Content Brief]

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