Glutamate-rich WD repeat-containing protein 1

Definition:

Histone binding-protein that regulates chromatin dynamics and minichromosome maintenance (MCM) loading at replication origins, possibly by promoting chromatin openness.

References:

[1]. Nozomi Sugimoto, et al. Cdt1-binding protein GRWD1 is a novel histone-binding protein that facilitates MCM loading through its influence on chromatin architecture. Nucleic Acids Res. 2015 Jul 13;43(12):5898-911. [Content Brief]

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