Glycodelin

Definition:

Glycoprotein that regulates critical steps during fertilization and also has immunomonomodulatory effects. Four glycoforms, namely glycodelin-S, -A, -F and -C have been identified in reproductive tissues that differ in glycosylation and biological activity. Glycodelin-A has contraceptive and immunosuppressive activities. Glycodelin-C stimulates binding of spermatozoa to the zona pellucida. Glycodelin-F inhibits spermatozoa-zona pellucida binding and significantly suppresses progesterone-induced acrosome reaction of spermatozoa. Glycodelin-S in seminal plasma maintains the uncapacitated state of human spermatozoa.

References:

[1]. J Rachmilewitz, et al. Placental protein 14 functions as a direct T-cell inhibitor. Cell Immunol. 1999 Jan 10;191(1):26-33. [Content Brief]

[2]. P C N Chiu, et al. Zona-binding inhibitory factor-1 from human follicular fluid is an isoform of glycodelin. Biol Reprod. 2003 Jul;69(1):365-72. [Content Brief]

[3]. Philip C N Chiu, et al. Glycodelin-S in human seminal plasma reduces cholesterol efflux and inhibits capacitation of spermatozoa. J Biol Chem. 2005 Jul 8;280(27):25580-9. [Content Brief]

[4]. Philip C N Chiu, et al. Cumulus oophorus-associated glycodelin-C displaces sperm-bound glycodelin-A and -F and stimulates spermatozoa-zona pellucida binding. J Biol Chem. 2007 Feb 23;282(8):5378-88. [Content Brief]

[5]. S Oehninger, et al. Factors affecting fertilization: endometrial placental protein 14 reduces the capacity of human spermatozoa to bind to the human zona pellucida. Fertil Steril. 1995 Feb;63(2):377-83. [Content Brief]

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