GRAM domain-containing protein 2A

Definition:

Participates in the organization of endoplasmic reticulum-plasma membrane contact sites (EPCS) with pleiotropic functions including STIM1 recruitment and calcium homeostasis. Constitutive tether that co-localize with ESYT2/3 tethers at endoplasmic reticulum-plasma membrane contact sites in a phosphatidylinositol lipid-dependent manner. Pre-marks the subset of phosphtidylinositol 4,5-biphosphate (PI(4,5)P2)-enriched EPCS destined for the store operated calcium entry pathway (SOCE).

References:

[1]. Marina Besprozvannaya, et al. GRAM domain proteins specialize functionally distinct ER-PM contact sites in human cells. Elife. 2018 Feb 22;7:e31019. [Content Brief]

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