Guanine nucleotide-binding protein-like 3

Definition:

May be required to maintain the proliferative capacity of stem cells. Stabilizes MDM2 by preventing its ubiquitination, and hence proteasomal degradation (By similarity).

References:

[1]. Robert Y L Tsai, et al. A nucleolar mechanism controlling cell proliferation in stem cells and cancer cells. Genes Dev. 2002 Dec 1;16(23):2991-3003. [Content Brief]

[2]. Chongxu Han, et al. Cloning of the nucleostemin gene and its function in transforming human embryonic bone marrow mesenchymal stem cells into F6 tumor cells. Int J Mol Med. 2005 Aug;16(2):205-13. [Content Brief]

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