Guanylate-binding protein 2

Definition:

Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions, but the major reaction product is GDP. Exhibits antiviral activity against influenza virus. Promotes oxidative killing and delivers antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes (By similarity). Confers protection to the protozoan pathogen Toxoplasma gondii (By similarity).

References:

[1]. R Neun, et al. GTPase properties of the interferon-induced human guanylate-binding protein 2. FEBS Lett. 1996 Jul 15;390(1):69-72. [Content Brief]

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