Guided entry of tail-anchored proteins factor CAMLG

Definition:

Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with GET1/WRB, acts as a membrane receptor for soluble GET3/TRC40, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. Required for the stability of GET1. Stimulates calcium signaling in T cells through its involvement in elevation of intracellular calcium. Essential for the survival of peripheral follicular B cells (By similarity).

References:

[1]. R J Bram, et al. Calcium signalling in T cells stimulated by a cyclophilin B-binding protein. Nature. 1994 Sep 22;371(6495):355-8. [Content Brief]

[2]. Alison J Inglis, et al. Differential Modes of Orphan Subunit Recognition for the WRB/CAML Complex. Cell Rep. 2020 Mar 17;30(11):3691-3698.e5. [Content Brief]

[3]. Fabio Vilardi, et al. WRB and CAML are necessary and sufficient to mediate tail-anchored protein targeting to the ER membrane. PLoS One. 2014 Jan 2;9(1):e85033. [Content Brief]

[4]. Yasunori Yamamoto, et al. Molecular machinery for insertion of tail-anchored membrane proteins into the endoplasmic reticulum membrane in mammalian cells. Mol Cell. 2012 Nov 9;48(3):387-97. [Content Brief]

[5]. Sara Francesca Colombo, et al. Tail-anchored Protein Insertion in Mammals: FUNCTION AND RECIPROCAL INTERACTIONS OF THE TWO SUBUNITS OF THE TRC40 RECEPTOR. J Biol Chem. 2016 Jul 15;291(29):15292-306. [Content Brief]

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