Hepatic angiosarcoma

Definition:

Angiosarcoma represents 1 to 2% of soft tissue tumors. It originates from endothelial cells of small blood vessels and may affect a variety of organs, including the retroperitoneum, skeletal muscle, subcutis, liver, heart and breast. Primary hepatic angiosarcomas (HAS) are much rare tumors, with worse prognosis compared with other angiosarcomas. HAS has been found to be caused by occupational exposure to vinyl chloride (VC) monomer since 1970, and the number of VC-associated HAS cases reported up to the end of 1998 was 197 worldwide. Exposure of VC connects with a series of mechanistic events leading to carcinogenic outcome; mutations of K-ras and p53 are also detected.

References:

[1]. P Chaudhary, et al. Primary hepatic angiosarcoma. Eur J Surg Oncol. 2015 Sep;41(9):1137-43. [Content Brief]

[2]. Robin J Young, et al. Angiosarcoma. Lancet Oncol. 2010 Oct;11(10):983-91. [Content Brief]

[3]. Ya-Wen Zheng, et al. Primary hepatic angiosarcoma and potential treatment options. J Gastroenterol Hepatol. 2014 May;29(5):906-11. [Content Brief]

[4]. Zhan-Bo Wang, et al. Transcription factor ERG is a specific and sensitive diagnostic marker for hepatic angiosarcoma. World J Gastroenterol. 2014 Apr 7;20(13):3672-9. [Content Brief]

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