Hepatocyte nuclear factor 1-alpha

Definition:

Transcriptional activator that regulates the tissue specific expression of multiple genes, especially in pancreatic islet cells and in liver (By similarity). Binds to the inverted palindrome 5'-GTTAATNATTAAC-3'. Activates the transcription of CYP1A2, CYP2E1 and CYP3A11 (By similarity).

References:

[1]. Young-In Chi, et al. Diabetes mutations delineate an atypical POU domain in HNF-1alpha. Mol Cell. 2002 Nov;10(5):1129-37. [Content Brief]

[2]. R B Rose, et al. Structural basis of dimerization, coactivator recognition and MODY3 mutations in HNF-1alpha. Nat Struct Biol. 2000 Sep;7(9):744-8. [Content Brief]

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