Histidine protein methyltransferase 1 homolog

Definition:

Protein-L-histidine N-tele-methyltransferase that specifically monomethylates RPL3, thereby regulating translation elongation. Histidine methylation of RPL3 regulates translation elongation by slowing ribosome traversal on tyrosine codons: slower elongation provides enough time for proper folding of synthesized proteins and prevents cellular aggregation of tyrosine-rich proteins.

References:

[1]. Eriko Matsuura-Suzuki, et al. METTL18-mediated histidine methylation of RPL3 modulates translation elongation for proteostasis maintenance. Elife. 2022 Jun 8;11:e72780. [Content Brief]

[2]. Jędrzej M Małecki, et al. Human METTL18 is a histidine-specific methyltransferase that targets RPL3 and affects ribosome biogenesis and function. Nucleic Acids Res. 2021 Apr 6;49(6):3185-3203. [Content Brief]

[3]. Philippe Cloutier, et al. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. PLoS Genet. 2013;9(1):e1003210. [Content Brief]

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