HMG box-containing protein 1

Definition:

Transcriptional repressor that binds to the promoter region of target genes. Plays a role in the regulation of the cell cycle and of the Wnt pathway. Binds preferentially to the sequence 5'-TTCATTCATTCA-3'. Binding to the histone H1.0 promoter is enhanced by interaction with RB1. Disrupts the interaction between DNA and TCF4.

References:

[1]. T Zhuma, et al. Human HMG box transcription factor HBP1: a role in hCD2 LCR function. EMBO J. 1999 Nov 15;18(22):6396-406. [Content Brief]

[2]. C Lemercier, et al. Involvement of retinoblastoma protein and HBP1 in histone H1(0) gene expression. Mol Cell Biol. 2000 Sep;20(18):6627-37. [Content Brief]

[3]. E M Sampson, et al. Negative regulation of the Wnt-beta-catenin pathway by the transcriptional repressor HBP1. EMBO J. 2001 Aug 15;20(16):4500-11. [Content Brief]

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