HMG-CoA reductase (HMGCR)

Definition:

HMG-CoA reductase (HMGCR) is a NADPH-dependent and rate-limiting enzyme of mevalonate (MVA) pathway. And HMG-CoA reductase (HMGCR) catalyzes the conversion of HMG-CoA to mevalonic acid, involves in biosynthesis of cholesterol.

References:

[1]. Schumacher MM, et al. Posttranslational Regulation of HMG CoA Reductase, the Rate-Limiting Enzyme in Synthesis of Cholesterol. Annu Rev Biochem. 2021 Jun 20;90:659-679. [Content Brief]

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