Homeobox protein NOBOX

Definition:

Transcription factor which may play a role in oogenesis. Binds preferentially to the DNA sequences 5'-TAATTG-3', 5'-TAGTTG-3' and 5'-TAATTA-3'.

References:

[1]. Ilaria Ferrari, et al. Impaired protein stability and nuclear localization of NOBOX variants associated with premature ovarian insufficiency. Hum Mol Genet. 2016 Dec 1;25(23):5223-5233. [Content Brief]

[2]. Justine Bouilly, et al. New NOBOX mutations identified in a large cohort of women with primary ovarian insufficiency decrease KIT-L expression. J Clin Endocrinol Metab. 2015 Mar;100(3):994-1001. [Content Brief]

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