Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein

Definition:

Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Could enhance presenilin-mediated amyloid-beta protein 40 generation. Binds to ubiquilins and this interaction is required for efficient degradation of CD3D via the ERAD pathway.

References:

[1]. Tae-Yeon Kim, et al. Herp enhances ER-associated protein degradation by recruiting ubiquilins. Biochem Biophys Res Commun. 2008 May 2;369(2):741-6. [Content Brief]

[2]. Jasmin Schulz, et al. Conserved cytoplasmic domains promote Hrd1 ubiquitin ligase complex formation for ER-associated degradation (ERAD). J Cell Sci. 2017 Oct 1;130(19):3322-3335. [Content Brief]

[3]. Andrea Schulze, et al. The ubiquitin-domain protein HERP forms a complex with components of the endoplasmic reticulum associated degradation pathway. J Mol Biol. 2005 Dec 16;354(5):1021-7. [Content Brief]

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