Hormone-sensitive lipase

Definition:

Lipase with broad substrate specificity, catalyzing the hydrolysis of triacylglycerols (TAGs), diacylglycerols (DAGs), monoacylglycerols (MAGs), cholesteryl esters and retinyl esters. Shows a preferential hydrolysis of DAGs over TAGs and MAGs and preferentially hydrolyzes the fatty acid (FA) esters at the sn-3 position of the glycerol backbone in DAGs. Preferentially hydrolyzes FA esters at the sn-1 and sn-2 positions of the glycerol backbone in TAGs (By similarity). Catalyzes the hydrolysis of 2-arachidonoylglycerol, an endocannabinoid and of 2-acetyl monoalkylglycerol ether, the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor (By similarity). In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production (By similarity).

References:

[1]. Jay Gao, et al. Identification of a novel keratinocyte retinyl ester hydrolase as a transacylase and lipase. J Invest Dermatol. 2005 Jun;124(6):1259-66. [Content Brief]

[2]. Jorge A Rodriguez, et al. In vitro stereoselective hydrolysis of diacylglycerols by hormone-sensitive lipase. Biochim Biophys Acta. 2010 Jan;1801(1):77-83. [Content Brief]

[3]. L S Holst, et al. Molecular cloning, genomic organization, and expression of a testicular isoform of hormone-sensitive lipase. Genomics. 1996 Aug 1;35(3):441-7. [Content Brief]

[4]. Yassine Ben Ali, et al. Continuous monitoring of cholesterol oleate hydrolysis by hormone-sensitive lipase and other cholesterol esterases. J Lipid Res. 2005 May;46(5):994-1000. [Content Brief]

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