Host cell factor C1 regulator 1

Definition:

Regulates HCFC1 activity by modulating its subcellular localization. Overexpression of HCFC1R1 leads to accumulation of HCFC1 in the cytoplasm. HCFC1R1-mediated export may provide the pool of cytoplasmic HCFC1 required for import of virion-derived VP16 into the nucleus.

References:

[1]. Shahana S Mahajan, et al. Interaction of HCF-1 with a cellular nuclear export factor. J Biol Chem. 2002 Nov 15;277(46):44292-9. [Content Brief]

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