Host-directed therapy (HDT)

Definition:

Host-directed therapeutics, also called host targeted therapeutics, act via a host-mediated response to pathogens rather than acting directly on the pathogen. Host-directed therapeutics may limit pathogen proliferation, e.g., have bacteriostatic effects.

References:

[1]. Hawn TR, Matheson AI, Maley SN, Vandal O. Host-directed therapeutics for tuberculosis: can we harness the host? Microbiol Mol Biol Rev. 2013 Dec;77(4):608-27. [Content Brief]

[2]. Paik S, et al. Autophagy: A new strategy for host-directed therapy of tuberculosis. Virulence. 2019 Dec;10(1):448-459. [Content Brief]

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