Hypochromic microcytic anemia

Definition:

Hypochromic microcytic anemia has been associated with a defect of iron absorption due to reduced iron entry into intestinal cells. Several isoforms of NRAMP2 (SLC11A2) are expressed ubiquitously in recycling endosomes or specifically at the apical membrane of epithelial cells in intestine and kidneys, and can contribute to iron overload, whereas mutations impairing NRAMP2 function cause a form of congenital hypochromic microcytic anemia.

References:

[1]. Bernard Grandchamp, et al. A novel type of congenital hypochromic anemia associated with a nonsense mutation in the STEAP3/TSAP6 gene. Blood. 2011 Dec 15;118(25):6660-6. [Content Brief]

[2]. P Courville, et al. Recent progress in structure-function analyses of Nramp proton-dependent metal-ion transporters. Biochem Cell Biol. 2006 Dec;84(6):960-78. [Content Brief]

[3]. R J Wood, et al. Recently identified molecular aspects of intestinal iron absorption. J Nutr. 1998 Nov;128(11):1841-4. [Content Brief]

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