Immune-responsive gene 1 ( IRG1)

Definition:

Immune-responsive gene 1 ( IRG1) is a mitochondrial enzyme that produces itaconate under inflammatory conditions, principally in cells of myeloid lineage.

References:

[1]. Nair S, et al. Irg1 expression in myeloid cells prevents immunopathology during M. tuberculosis infection. J Exp Med. 2018 Apr 2;215(4):1035-1045. [Content Brief]

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