Immunodepleted Coimmunoprecipitation

Definition:

Immunodepleted Coimmunoprecipitation is a technique used to study protein-protein interactions through consecutive co-immunoprecipitations. In the experiment, specific antibodies are used to deplete target interacting proteins or alter the composition of complexes, further validating the specificity of protein interactions. This technique is widely applied in cell signaling research and protein interaction network analysis.

References:

[1]. oukov V, et al. The BRCA1/BARD1 heterodimer modulates ran-dependent mitotic spindle assembly. Cell. 2006 Nov 3;127(3):539-52. [Content Brief]

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