Immunoglobulin superfamily member 8

Definition:

May play a key role in diverse functions ascribed to CD81 and CD9 such as oocytes fertilization or hepatitis C virus function. May regulate proliferation and differentiation of keratinocytes. May be a negative regulator of cell motility: suppresses T-cell mobility coordinately with CD81, associates with CD82 to suppress prostate cancer cell migration, regulates epidermoid cell reaggregation and motility on laminin-5 with CD9 and CD81 as key linkers. May also play a role on integrin-dependent morphology and motility functions. May participate in the regulation of neurite outgrowth and maintenance of the neural network in the adult brain.

References:

[1]. Tatiana V Kolesnikova, et al. EWI-2 modulates lymphocyte integrin alpha4beta1 functions. Blood. 2004 Apr 15;103(8):3013-9. [Content Brief]

[2]. C S Stipp, et al. EWI-2 is a major CD9 and CD81 partner and member of a novel Ig protein subfamily. J Biol Chem. 2001 Nov 2;276(44):40545-54. [Content Brief]

[3]. Christopher S Stipp, et al. EWI-2 regulates alpha3beta1 integrin-dependent cell functions on laminin-5. J Cell Biol. 2003 Dec 8;163(5):1167-77. [Content Brief]

[4]. M Bonkobara, et al. Identification of novel genes for secreted and membrane-anchored proteins in human keratinocytes. Br J Dermatol. 2003 Apr;148(4):654-64. [Content Brief]

[5]. Xin A Zhang, et al. EWI2/PGRL associates with the metastasis suppressor KAI1/CD82 and inhibits the migration of prostate cancer cells. Cancer Res. 2003 May 15;63(10):2665-74. [Content Brief]

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