Inactive heparanase-2

Definition:

Binds heparin and heparan sulfate with high affinity, but lacks heparanase activity. Inhibits HPSE, possibly by competing for its substrates (in vitro).

References:

[1]. Flonia Levy-Adam, et al. Heparanase 2 interacts with heparan sulfate with high affinity and inhibits heparanase activity. J Biol Chem. 2010 Sep 3;285(36):28010-9. [Content Brief]

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