Inositol polyphosphate-5-phosphatase A

Definition:

Phosphatase that specifically hydrolyzes the 5-phosphate of inositol 1,4,5-trisphosphate to inositol 1,4-bisphosphate, and inositol 1,3,4,5-tetrasphosphate to inositol 1,3,4-trisphosphate. Plays a crucial role in the survival of cerebellar Purkinje cells (By similarity).

References:

[1]. F De Smedt, et al. Post-translational modification of human brain type I inositol-1,4,5-trisphosphate 5-phosphatase by farnesylation. J Biol Chem. 1996 Apr 26;271(17):10419-24. [Content Brief]

[2]. F De Smedt, et al. Cloning and expression of human brain type I inositol 1,4,5-trisphosphate 5-phosphatase. High levels of mRNA in cerebellar Purkinje cells. FEBS Lett. 1994 Jun 20;347(1):69-72. [Content Brief]

[3]. A L Drayer, et al. Cloning and expression of a human placenta inositol 1,3,4,5-tetrakisphosphate and phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase. Biochem Biophys Res Commun. 1996 Aug 5;225(1):243-9. [Content Brief]

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