Intelectin-1

Definition:

Lectin that specifically recognizes microbial carbohydrate chains in a calcium-dependent manner. Binds to microbial glycans that contain a terminal acyclic 1,2-diol moiety, including beta-linked D-galactofuranose (beta-Galf), D-phosphoglycerol-modified glycans, D-glycero-D-talo-oct-2-ulosonic acid (KO) and 3-deoxy-D-manno-oct-2-ulosonic acid (KDO). Binds to glycans from Gram-positive and Gram-negative bacteria, including K.pneumoniae, S.pneumoniae, Y.pestis, P.mirabilis and P.vulgaris. Does not bind human glycans. Probably plays a role in the defense system against microorganisms (Probable). May function as adipokine that has no effect on basal glucose uptake but enhances insulin-stimulated glucose uptake in adipocytes. Increases AKT phosphorylation in the absence and presence of insulin. May interact with lactoferrin/LTF and increase its uptake, and may thereby play a role in iron absorption.

References:

[1]. Darryl A Wesener, et al. Recognition of microbial glycans by human intelectin-1. Nat Struct Mol Biol. 2015 Aug;22(8):603-10. [Content Brief]

[2]. Y A Suzuki, et al. Molecular cloning and functional expression of a human intestinal lactoferrin receptor. Biochemistry. 2001 Dec 25;40(51):15771-9. [Content Brief]

[3]. S Tsuji, et al. Human intelectin is a novel soluble lectin that recognizes galactofuranose in carbohydrate chains of bacterial cell wall. J Biol Chem. 2001 Jun 29;276(26):23456-63. [Content Brief]

[4]. Rong-Ze Yang, et al. Identification of omentin as a novel depot-specific adipokine in human adipose tissue: possible role in modulating insulin action. Am J Physiol Endocrinol Metab. 2006 Jun;290(6):E1253-61. [Content Brief]

[5]. Yuka Akiyama, et al. A lactoferrin-receptor, intelectin 1, affects uptake, sub-cellular localization and release of immunochemically detectable lactoferrin by intestinal epithelial Caco-2 cells. J Biochem. 2013 Nov;154(5):437-48. [Content Brief]

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