Interferon-induced GTP-binding protein Mx1

Definition:

Interferon-induced dynamin-like GTPase with antiviral activity against a wide range of RNA viruses and some DNA viruses. Its target viruses include negative-stranded RNA viruses and HBV through binding and inactivation of their ribonucleocapsid. May also antagonize reoviridae and asfarviridae replication. Inhibits thogoto virus (THOV) replication by preventing the nuclear import of viral nucleocapsids. Inhibits La Crosse virus (LACV) replication by sequestering viral nucleoprotein in perinuclear complexes, preventing genome amplification, budding, and egress. Inhibits influenza A virus (IAV) replication by decreasing or delaying NP synthesis and by blocking endocytic traffic of incoming virus particles. Enhances ER stress-mediated cell death after influenza virus infection. May regulate the calcium channel activity of TRPCs.

References:

[1]. Georg Kochs, et al. Assay and functional analysis of dynamin-like Mx proteins. Methods Enzymol. 2005;404:632-43. [Content Brief]

[2]. Anne Bridgen, et al. Inhibition of Dugbe nairovirus replication by human MxA protein. Virus Res. 2004 Jan;99(1):47-50. [Content Brief]

[3]. Christopher L Netherton, et al. Inhibition of a large double-stranded DNA virus by MxA protein. J Virol. 2009 Mar;83(5):2310-20. [Content Brief]

[4]. Ida Andersson, et al. Human MxA protein inhibits the replication of Crimean-Congo hemorrhagic fever virus. J Virol. 2004 Apr;78(8):4323-9. [Content Brief]

[5]. Egbert Mundt, et al. Human MxA protein confers resistance to double-stranded RNA viruses of two virus families. J Gen Virol. 2007 Apr;88(Pt 4):1319-1323. [Content Brief]

[6]. Marc P Lussier, et al. MxA, a member of the dynamin superfamily, interacts with the ankyrin-like repeat domain of TRPC. J Biol Chem. 2005 May 13;280(19):19393-400. [Content Brief]

[7]. M Leroy, et al. Expression of the interferon-alpha/beta-inducible bovine Mx1 dynamin interferes with replication of rabies virus. Neurobiol Dis. 2006 Mar;21(3):515-21. [Content Brief]

[8]. Mike Reichelt, et al. Missorting of LaCrosse virus nucleocapsid protein by the interferon-induced MxA GTPase involves smooth ER membranes. Traffic. 2004 Oct;5(10):772-84. [Content Brief]

[9]. Zhijian Yu, et al. GTPase activity is not essential for the interferon-inducible MxA protein to inhibit the replication of hepatitis B virus. Arch Virol. 2008;153(9):1677-84. [Content Brief]

[10]. Georg Kochs, et al. Antivirally active MxA protein sequesters La Crosse virus nucleocapsid protein into perinuclear complexes. Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):3153-8. [Content Brief]

[11]. Akiko Numajiri Haruki, et al. Interferon-inducible antiviral protein MxA enhances cell death triggered by endoplasmic reticulum stress. J Interferon Cytokine Res. 2011 Nov;31(11):847-56. [Content Brief]

[12]. Kadir Turan, et al. Nuclear MxA proteins form a complex with influenza virus NP and inhibit the transcription of the engineered influenza virus genome. Nucleic Acids Res. 2004 Jan 29;32(2):643-52. [Content Brief]

[13]. Alexander von der Malsburg, et al. Stalk domain of the dynamin-like MxA GTPase protein mediates membrane binding and liposome tubulation via the unstructured L4 loop. J Biol Chem. 2011 Oct 28;286(43):37858-65. [Content Brief]

Biomedical Dictionary

The Biomedical Dictionary is a comprehensive and professional collection of biological academic terms and subject datas. All explanations are supported by authoritative books or high impact factor literatures, and you can acquire accurate explanations of the biomedical terms you want to know.

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z #

Name
Email *

	Sorry, but the email address you supplied was invalid.